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PATENTS

  1. Sunil A. David, Janardhan Banothu, Mallesh Beesu and Michael Brush. Therapeutic compounds and methods of use thereof, U.S. Patent Number: US11014921B2. Application granted on 25/05/2021.

  2. Sunil A. David, Janardhan Banothu, Michael Brush, Collin Gustafson and Kathryn Trautman. Therapeutic compounds and methods of use thereof, U.S. Patent Number: US11465998B2. Application granted on 11/10/2022.

  3. Janardhan Banothu, Arya C. G. A Regioselective Synthesis of 1,2-Disubstituted Benzimidazole, Indian Patent Number: 461737. Application granted on 25/10/2023.

  4. Janardhan Banothu, Arya C. G. A Regioselective Synthesis of 2-Disubstituted Benzimidazole, Indian Patent Number: 500238. Application granted on 17/01/2024. 

  5. Janardhan Banothu, Neethu Mariam Thomas. 6-Fluoro-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide derivatives as chemotherapeutic agents and synthetic method thereof, Indian Patent Number: 557540. Application granted on 07/01/2025. 

PUBLICATIONS

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 Publications From NITC​​​​

  1. Arya C G, Jyothi Kumari, Jai Kishan, Kamini Goswami, Dharmarajan Sriram, Simi Asma Salim, Paramita Pakhira, Siddhardha Busi, Majed Alharbi, Munugala Chandrakanth, Mukesh Pasupuleti and Janardhan Banothu.* 2-Substituted and 1,2-disubstitued benzimidazole derivatives: Synthesis and identification of potential antibacterial agents. Journal of Molecular Structure, 2025, 1333, 141693. https://doi.org/10.1016/j.molstruc.2025.141693

  2. Neethu Mariam Thomas, Majeb Alharbi, Venkanna Muripiti and  Janardhan Banothu.*  Quinoline and quinolone carboxamides: A review of anticancer activity with detailed structure–activity relationship analysis. Molecular Diversity, 2025. https://doi.org/10.1007/s11030-024-11092-4 

  3. Ashok Kumar Madikonda, Amritha Ajayakumar, Sudeena Nadendla, Janardhan Banothu and Venkanna Muripiti.* Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits. Bioorganic & Medicinal Chemistry, 2024, 116, 118001. https://doi.org/10.1016/j.bmc.2024.118001

  4. Rajitha Gali, Janardhan Banothu, Punam Salaria, N. N. Subrahmanyeswara Rao, Santosh Kumar Badampudi, and M. Amarendar Reddy.* Fused Thiazolo[2,3‐b]Quinazolinone–Chromone Hybrids: Synthesis, Characterization, In Vitro Antibacterial Activity and In Silico Screening. Journal of Heterocyclic Chemistry, 2024, 0, 1–11. https://doi.org/10.1002/jhet.4892

  5. Arya C.G, Raj Kishore, Pooja Gupta, Ramesh Gondru, Jesu Arockiaraj, Mukesh Pasupuleti, Munugala Chandrakanth, Punya V.P and Janardhan Banothu.* Identification of coumarin – benzimidazole hybrids as potential antibacterial agents: Synthesis, in vitro and in vivo biological assessment, and ADMET prediction. Bioorganic & Medicinal Chemistry Letters, 2024, 110, 129881. https://doi.org/10.1016/j.bmcl.2024.129881

  6. Praveen Telukuntla, Munugala Chandrakanth, Amrutha P.G, Neethu Mariam Thomas, Ramesh Gondru, Krishna Reddy Valluru, Janardhan Banothu.* 1,2,3-Triazole – [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids: A switch for improvement of antibreast cancer activity targeting epidermal growth factor receptor. Tetrahedron Letters, 2024, 146, 155180. https://doi.org/10.1016/j.tetlet.2024.155180 

  7. Fabitha K, Anoop Kallingal, Natalia Maciejewska, Arya C G, Munugala Chandrakanth, Neethu Mariam Thomas, Yupeng Li, Ramesh Gondru, Manne Munikumar and Janardhan Banothu.* Novel Fused Pyran Derivatives Induce Apoptosis and Target Cell Cycle Progression in Anticancer Efficacy against Multiple Cell Lines. New Journal of Chemistry, 2024, 48, 8038-8054. https://doi.org/10.1039/D4NJ00824C 

  8. Venkanna Muripiti*, Venkatesh Ravula, Srinivas Batthula, Janardhan Banothu, Ramesh Gondru.* Phenylboronic acid-derived nanovectors for gene/drug delivery by targeting cell surface glycans. RSC Pharmaceutics, 2024, 1 (3), 403-411. https://doi.org/10.1039/D4PM00005

  9. Arya C G, Munugala Chandrakanth, Fabitha K, Neethu Mariam Thomas, Bhargava Sai Allaka, Srinivas Basavoju, Sonyanaik Banoth and Janardhan Banothu.* Sodium fluoride-assisted, solvent-controlled regioselective synthesis of 2-substituted and 1,2-disubstituted benzimidazoles with diverse substituents, and unveiling mechanistic insights. Journal of Molecular Structure, 2024, 1306, 137935. https://doi.org/10.1016/j.molstruc.2024.137935

  10. Amrutha P G, Sonyanaik Banoth, Janardhan Banothu.* Neuroimmunomodulatory properties of laquinimod.
    Brain Disorders, 2024, 13, 100119. https://doi.org/10.1016/j.dscb.2024.100119

  11. Venkanna Muripiti, Amarnath Velidandia, Yash Paul Sharma, Ramesh Gondru, C.G. Arya, Janardhan Banothu.* Targeted gene delivery through receptors with lipid nanoparticles. Journal of Drug Delivery Science and Technology, 2024, 93, 105457. https://doi.org/10.1016/j.jddst.2024.105457

  12. Munugala Chandrakanth, Neethu Mariam Thomas, Arya C G, Fabitha K, Janardhan Banothu.* Coumarin–1,2,4-triazole hybrids: Recent advances in synthesis and medicinal applications. Journal of Molecular Structure, 2024, 1299, 137197. https://doi.org/10.1016/j.molstruc.2023.137197

  13. A P Naseer, P K Madhavan Unni, Janardhan Banothu.* Light scattering investigations in the system methyl ethyl ketone + water + secondary butyl alcohol with traces of potassium thiocyanate. Journal of Molecular Liquids, 2023, 383, 122081. https://doi.org/10.1016/j.molliq.2023.122081

  14. Fabitha K, Arya C G, Munugala Chandrakanth and Janardhan Banothu.* Green Chemistry Approach: Sodium Fluoride-Catalysed Highly Efficient Microwave Irradiation-Assisted Synthesis of Substituted Chromene Derivatives in Aqueous Medium. Research on Chemical Intermediates, 2023, 49, 997–1014. https://doi.org/10.1007/s11164-022-04929-w

  15. Fabitha K, Arya C G, Shyam Perugu, Ramesh Gondru, Janardhan Banothu.* 1,2,3-Triazole linked Chalcone-Morpholine hybrids: Synthesis, in vitro Antibacterial Evaluation and in silico ADMET Predictions. Polycyclic Aromatic Compounds, 2023, 43 (8), 7093–7109. https://doi.org/10.1080/10406638.2022.2130369  

  16. Arya C G, Munugala Chandrakanth, Fabitha K, Neethu Mariam Thomas, Rakendu N Pramod, Ramesh Gondru* and Janardhan Banothu.* Coumarin - Benzimidazole Hybrids: A Review on Diverse Synthetic Strategies. Results in Chemistry, 2022, 4, 100631. https://doi.org/10.1016/j.rechem.2022.100631

  17. Fabitha K, Munugala Chandrakanth, Rakendu N Pramod, Arya C G, Yupeng Li and Janardhan Banothu.* Recent Developments in the Synthesis of Indole-Pyrazole Hybrids. ChemistrySelect, 2022, 7, e202201064. https://doi.org/10.1002/slct.202201064

  18. Arya C G, Ramesh Gondru, Yupeng Li* and Janardhan Banothu.* Coumarin–Benzimidazole Hybrids: A Review of Developments in Medicinal Chemistry. European Journal of Medicinal Chemistry, 2022, 227, 113921. https://doi.org/10.1016/j.ejmech.2021.113921

  19. Ramesh Gondru, Sirisha Kanugala, Sneha Raj, C Ganesh Kumar, Mukesh Pasupuleti, Janardhan Banothu and Rajith Bavantula*. 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. Bioorganic Medicinal Chemistry Letters, 2021, 33,  127746. https://doi.org/10.1016/j.bmcl.2020.127746

  20. Rajitha Deshineni, Arya C G, Janardhan Banothu*, Ravibabu Velpula and Gyanakumari Chellamella*. Synthesis, anticancer and antibacterial evaluation of novel 1,3-disubstituted-1H-pyrazole-4-yl-methylene embedded fused thiazolo[2,3-b]quinazolinones. Chemical Data Collections, 2020, 30, 100546. https://doi.org/10.1016/j.cdc.2020.100546

  21. Rajitha Gali, Arya C G, Janardhan Banothu*, S. V. Laxmi, G. Ramesh and U. Sujana Kumari. 3-Aryl/heteryl-5-phenylindeno[1,2-d]thiazolo[3,2-a]pyrimidin-6(5H)-ones: Synthesis, characterization and antimicrobial investigation. Russian Journal of Bioorganic Chemistry, 2020, 46(4), 612-619. https://doi.org/10.1134/S106816202004007X

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 Publications from Ph.D. and Post-Doc.

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  1. Ziwei Hu, Janardhan Banothu, Mallesh Beesu, Collin J. Gustafson, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer, Balaji Pathakumari, and Sunil A. David.* Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides. ACS Medicinal Chemistry Letters, 2019, 10, 132−136. (First three authors have equal contributions). https://doi.org/10.1021/acsmedchemlett.8b00540  

  2. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula.* Brønsted acidic ionic liquid catalyzed an efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles under solvent-free conditions. Arabian Journal of Chemistry, 2017, 10, S2754–S2761. https://doi.org/10.1016/j.arabjc.2013.10.022  

  3. Janardhan Banothu, Rajitha Bavantula* and Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones. Journal of Saudi Chemical Society, 2016, 20, S221–S226. https://doi.org/10.1016/j.jscs.2012.10.007

  4. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali and Rajitha Bavantula.* Synthesis of novel fused thiazolo[3,2-a]pyrimidin-3-ols and evaluation for their antibacterial activity. Journal of Heterocyclic Chemistry, 2016, 53, 51-55. https://doi.org/10.1002/jhet.2281 

  5. Ramesh Gondru, Janardhan Banothu, Ranjith Kumar Thatipamula, Althaf Hussain SK and Rajitha Bavantula*. 3-(1-Phenyl-4-((2-(4-arylthiazol-2-yl)hydrazono)-methyl)-1H-pyrazol-3-yl)-2H-chromen-2-ones: one-pot three component condensation, in vitro antimicrobial, antioxidant and molecular docking studies. RSC Advances, 2015, 5, 33562-33569. https://doi.org/10.1039/C5RA04196A 

  6. Rajitha Gali, Janardhan Banothu, Ramesh Gondru, Rajitha Bavantula*, Yashodhara Velivela and Peter A. Crooks. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 106–112. https://doi.org/10.1016/j.bmcl.2014.10.100

  7. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Deshineni and Rajitha Bavantula*. 1-Sulfopyridinium chloride: Green and expeditious ionic liquid for the one-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent free conditions. Chinese Chemical Letters, 2015, 26, 309–312. https://doi.org/10.1016/j.cclet.2014.11.030

  8. Janardhan Banothu, Srinivas Basavoju and Rajitha Bavantula*. Pyridinium ylide assisted highly stereoselective one-pot synthesis of trans-2-(4-chlorobenzoyl)-3-aryl-spiro [cyclopropane-1,2′-inden]-1′,3′-diones and their antimicrobial and nematicidal activities. Journal of Heterocyclic Chemistry, 2015, 52, 853-860. https://doi.org/10.1002/jhet.2059

  9. Rajitha Gali, Janardhan Banothu, Rajitha Bavantula*. One-pot multicomponent synthesis of novel substituted imidazo[1,2-a]pyridine incorporated thiazolylcoumarins and their antimicrobial activity. Journal of Heterocyclic Chemistry, 2015, 52, 641-646. https://doi.org/10.1002/jhet.2116  

  10. Gondru Ramesh, Janardhan Banothu and Rajitha Bavantula*. Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation. Results on Chemical Intermediates, 2015, 41, 8099–8109. https://doi.org/10.1007/s11164-014-1879-z 

  11. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam and Rajitha Bavantula*. One pot and solvent-free synthesis of 3-(9-hydroxy-3-methoxy-7-aryl-6,7,9,10-tetrahydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9-yl)-2H-chromen-2-ones and their antibacterial evaluation. Turkish Journal of Chemistry, 2015, 39, 620 – 629. https://doi.org/10.3906/kim-1410-64

  12. Janardhan Banothu, Manjulatha Khanapur, Srinivas Basavoju, Rajitha Bavantula*, Muralikrishna Narra and Sadanandam Abbagani. Synthesis, characterization and biological evaluation of fused thiazolo[3,2-a]pyrimidine derivatives. RSC Advances, 2014, 4, 22866-22874. https://doi.org/10.1039/C4RA02514H

  13. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Rajitha Bavantula*, and Sadanandam Abbagani. Synthesis and in vitro cytotoxic activity of novel coumarinylimidazo[2,1-b]thiazole derivatives. RSC Advances, 2014, 4, 53812-53819. https://doi.org/10.1039/C4RA11428K

  14. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Sairengpuii Hnamte, Rajitha Bavantula*, Sadanandam Abbagani and Siddhardha Busi. Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: Synthesis, characterization and evaluation of anticancer and antimicrobial activities. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 4239–4242. https://doi.org/10.1016/j.bmcl.2014.07.030

  15. Janardhan Banothu, Srinivas Basavoju, Rajitha Bavantula* and Peter A. Crooks. Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks. Tetrahedron Letters, 2014, 55, 224–226. https://doi.org/10.1016/j.tetlet.2013.11.001

  16. Janardhan Banothu, Rajitha Bavantula* and Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient heterogeneous catalyst for the one-pot synthesis of polyhydroquinolines via unsymmetrical Hantzsch reaction in aqueous medium. Journal of Saudi Chemical Society, 2014, 18, 722–727. https://doi.org/10.1016/j.jscs.2014.01.009

  17. Janardhan Banothu, Krishnaiah Vaarla, Rajitha Bavantula* and Peter A. Crooks. Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature. Chinese Chemical Letters, 2014, 25, 172-175. https://doi.org/10.1016/j.cclet.2013.10.001

  18. Ravibabu Velpula, Janardhan Banothu, Acharya Nagarjun Pyde and Rajitha Bavantula*. Synthesis of thioalkylated-4-aryltetrahydroquinazolinone derivatives and their antibacterial activity. Organic Communications, 2014, 7, 45-52. shorturl.at/suCES 

  19. Janardhan Banothu, Ravibabu Velpula, Rajitha Gali, Rajitha Bavantula* and Peter A. Crooks. Highly efficient conversion of fused 2-amino-4-aryl-4H-chromene-3-carbonitriles into fused 2-oxo-4-aryl-2H-chromene-3-carbonitriles using Vilsmeier conditions. Tetrahedron Letters, 2013, 54, 3862–3864. https://doi.org/10.1016/j.tetlet.2013.05.030

  20. Janardhan Banothu, S. Vijayalaxmi and Rajitha Bavantula*. Sulfamic acid-catalyzed multicomponent one-pot synthesis of polysubstituted pyridines and their antimicrobial activity. Journal of Heterocyclic Chemistry, 2013, 50, 1230-1235. https://doi.org/10.1002/jhet.1564

  21. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula and Rajitha Bavantula.* Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyranopyrimidinones and their antimicrobial activity. Journal of Chemical Sciences, 2013, 125, 843-849. https://doi.org/10.1007/s12039-013-0459-x

  22. Janardhan Banothu, Rajitha Bavantula* and Anthony Peter Crooks. Poly(4-vinylpyridinium) hydrogen sulfate catalyzed an efficient and eco-friendly protocol for the one-pot multicomponent synthesis of 1,8-acridinediones in aqueous medium. Journal of Chemistry, 2013, 1-6. https://doi.org/10.1155/2013/850254 

  23. Janardhan Banothu, Rajitha Bavantula,* and Anthony Peter Crooks. Facile one-pot multicomponent synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylpyridine-3-carbonitriles using Brønsted acidic ionic liquid as catalyst under solvent-free conditions. Iranian Journal of Catalysis, 2013, 3, 41-47. shorturl.at/oAHQ9

  24. Janardhan Banothu, Rajitha Bavantula*. Brønsted acidic ionic liquid catalyzed highly efficient synthesis of chromeno-pyrimidinone derivatives and their antimicrobial activity. Chinese Chemical Letters, 2012, 23, 1015-1018. https://doi.org/10.1016/j.cclet.2012.06.041

  25. Kuarm, B. Suresh., Janardhan Banothu, Anthony Peter Crooks and Rajitha Bavantula.* Xanthan sulfuric acid: An efficient bio-supported and recyclable solid acid catalyst for the synthesis of 2-aryl thiadiazolobenzimidazoles. Chinese Journal of Chemistry, 2012, 30, 947-950. https://doi.org/10.1002/cjoc.201100137

  26. Somarapu VijayaLaxmi, Janardhan Banothu, Rajitha Bavantula*, P. Raghavaiah and Prathima Srinivas. Synthesis, single crystal X-ray studies and antimicrobial activities of novel indole barbiturates. Medicinal Chemistry Research, 2012, 21, 2896-2901. https://doi.org/10.1007/s00044-011-9827-6

  27. Janardhan Banothu, Somarapu VijayaLaxmi and Rajitha Bavantula*. One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli-like scaffolds. Heterocyclic Communications, 2012, 18, 93-97. https://doi.org/10.1515/hc-2011-0109

  28. Janardhan Banothu, V. Ravibabu, Anthony Peter Crooks, Rajitha Bavantula*. L-proline catalyzed an efficient multicomponent one-pot synthesis of poly substituted pyridines. Organic Communications, 2012, 5, 186-195. 

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DEPT CHEM.png
Office:
Room No.: 210(C)
Department of Chemistry, NIT Calicut
Kozhikhode - 673 601, Kerala, India

Email: janardhan@nitc.ac.in

Phone: +91-495-228-5324

Mobile: +91-8111938615

Laboratory:
Heterocyclic Chemistry Laboratory

Room No.: 109, Ground Floor

Department of Chemistry, NIT  Calicut
Kozhikode - 673 601, Kerala, India

Phone: +91-495-228-5321

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Medicinal Chemistry Laboratory

Room: Second Floor

Department of Chemistry, NIT  Calicut
Kozhikode - 673 601, Kerala, India

Phone: +91-495-228-5345

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